Bupropion is an atypical antidepressant also used for smoking cessation support and seasonal affective disorder. It is a norepinephrine-dopamine reuptake inhibitor and is marketed under brands including Wellbutrin and Zyban. The medicine is prescription-only and has been in U.S. clinical use since the 1980s.
A secondary analysis of the OPTIMUM trial found that higher doses of bupropion and prior fall history significantly increase fall risk in older adults with treatment-resistant depression receiving antidepressant augmentation.
Systematic review identifies shared molecular signatures in brain and blood for major depressive disorder, while separate study finds brain-enriched circRNA can predict SSRI treatment response.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07596212 |
BRE-06: Study to Increase Tolerance to Aromatase Inhibitors for Patients With Early-Stage Hormone Receptor Positive Breast Cancer Who Developed Hypoactive Sexual Desire Disorder |
NOT_YET_RECRUITING | PHASE1/PHASE2 |
| NCT07584434 |
A Phase 1, First-in-human Study of VX-433 |
NOT_YET_RECRUITING | PHASE1 |
| NCT07235748 |
Drug-drug Interaction Study of Vorasidenib With Bupropion, Repaglinide, Flurbiprofen, Omeprazole, Midazolam, and Rosuvastatin in Healthy Adult Participants |
COMPLETED | PHASE1 |
| NCT07223671 |
Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants |
COMPLETED | PHASE1 |
| NCT06973005 |
A Study to Investigate How Multiple Oral Doses of AZD2389 Affect the Pharmacokinetics of Midazolam, Caffeine, and Bupropion in Healthy Participants |
COMPLETED | PHASE1 |
| NCT06679413 |
A Study to Assess Drug-drug Interaction of ZX008 in Healthy Male and Female Study Participants |
COMPLETED | PHASE1 |
| NCT06564441 |
A Study to Test Whether BI 456906 (Survodutide) Influences the Amount of Bupropion, Caffeine and Midazolam in the Blood in People With Overweight or Obesity |
COMPLETED | PHASE1 |
| NCT06374290 |
Study of Injectable Naltrexone and Oral Bupropion Among Cigarette Smokers With Schizophrenia |
TERMINATED | PHASE1 |
| NCT06367153 |
A Study in Healthy Men and Women to Test Whether BI 1569912 Influences the Amount of Repaglinide, Midazolam and Bupropion in the Blood |
COMPLETED | PHASE1 |
| NCT06254001 |
Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects |
RECRUITING | PHASE4 |
