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ACE Inhibitors Combined With Exercise for Seniors - Pilot Study

NCT01891513 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 104

Last updated 2017-07-05

No results posted yet for this study

Summary

The purpose of this study is to compare, when combined with chronic exercise, the effects of perindopril, losartan, and hydrochlorothiazide.

Conditions

Interventions

BEHAVIORAL

Exercise

All participants will take part in 3 days/week of structured aerobic, stretching, and balance training for weeks 1-12. For weeks, 13-24, training will be reduced to 2 days/week and a resistance training component added. Participants will also be expected to engage in 2 bouts of 30 minutes of home-based walking per week.

DRUG

ACE inhibitor + exercise

In addition to exercise training, participants will receive an initial perindopril dose of 2 mg/day which will be titrated to 4 mg/day.

DRUG

Thiazide diuretic + exercise

In addition to exercise training, participants will receive an initial hydrochlorothiazide dose of 12.5 mg/day which will be titrated to 25 mg/day.

DRUG

Angiotensin receptor blocker + exercise

In addition to exercise training, participants will receive an initial losartan dose of 50 mg/day which will be titrated to 100 mg/day.

Sponsors & Collaborators

Principal Investigators

  • Thomas Buford, Ph.D. · University of Florida Department of Aging and Geriatric Research

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-01-31
Primary Completion
2017-06-30
Completion
2017-06-30

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01891513 on ClinicalTrials.gov