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ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension

NCT03295734 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 223

Last updated 2025-07-22

Study results available
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Summary

The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older persons with hypertension when combined with physical exercise.

Conditions

Interventions

BEHAVIORAL

Aerobic exercise

Twice weekly centered based aerobic exercise + 3/week home-based walking

DRUG

Perindopril

4 mg qd titrated to 8 mg qd perindopril

DRUG

Losartan

50 mg qd titrated to 100 qd losartan

DRUG

HCTZ

12.5 mg qd titrated to 25 qd HCTZ

Sponsors & Collaborators

  • University of Colorado, Denver

    collaborator OTHER

  • AdventHealth Translational Research Institute

    collaborator OTHER

  • University of Alabama at Birmingham

    lead OTHER

Principal Investigators

  • Thomas Buford, PhD · University of Alabama at Birmingham

  • Bret Goodpaster, PhD · Translational Research Institute, Advent Health

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-05-29
Primary Completion
2024-09-19
Completion
2024-09-19
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03295734 on ClinicalTrials.gov