Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder

Summary

Adoption, twin and family studies have reported that obesity has a strong heritable component and in particular, it has been suggested that BMI in adults is due to genetic influence rather than shared family environment. Binge eating in obese patients was described. Therefore, it has been proposed that binge eating disorder (BED) may contribute to obesity in some individuals.

Pharmacological studies reported that topiramate plays an important role in the treatment of binge eating disorder. It has been observed improvement of co-occurring binge eating disorder in patients receiving topiramate for treatment of mood disorders. In addition, topiramate was associated with anorexia and weight loss in clinical trials with epilepsy patients. Also, topiramate has been demonstrated efficacy in pilot and controlled studies for binge eating disorder (BED) associated with obesity. Genetic studies will be important to elucidate the mechanism by which putative susceptibility variation in candidate genes influences in pharmacological improvement of binge eating disorder in obese patients treated with topiramate.

Connecting drug response with relevant functional DNA variants and differences in brain regions represents the ultimate goal for pharmacogenetic research playing an important role in advancing this understanding. The use of brain imaging combined with genetics can aid in understanding the pathophysiological mechanism of the disease. Additionally, brain imaging has the ability to bridge between preclinical research and human pharmacological studies.

This will be a naturalistic clinical study designed to analyze the effect of genetic variants and neurofunctional brain areas associated with food craving in patients with obesity and binge eating disorder responders to topiramate.

Hypothesis: The use of topiramate in obese subjects with binge eating disorder is associated with a differential gene variants and different activation brain areas in subjects that showed a reduction of food craving and weight lost.

Conditions

• Obesity
• Binge Eating Disorder

Sponsors & Collaborators

• Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente

  lead OTHER

Principal Investigators

• Beatriz E Camarena, PhD · Instituto Nacional de Psiquiatria Dr. Ramon de la Fuente

• Alejandro Caballero, M.D. · Instituto Nacional de Psiquiatria Dr. Ramon de la Fuente

• Juan J Cervantes, M.D. · Instituto Nacional de Psiquiatria Dr. Ramon de la Fuente

• Griselda Flores, M.D. · Instituto Nacional de Psiquiatria Dr. Ramon de la Fuente

• Sandra Hernandez, B,Sc. · Instituto Nacional de Psiquiatria Dr. Ramon de la Fuente

Eligibility

Min Age

18 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-06-30

Primary Completion

2013-12-31

Completion

2014-03-31

Countries

• Mexico

Study Locations