Sustainable East Africa Research in Community Health

Summary

The SEARCH study aims to test evidenced-based innovative community based interventions that lead to the elimination of HIV in rural communities in East Africa using a multi-disease approach. The first phase of the study will quantify the impact of early HIV diagnosis using a streamlined and immediate ART (antiretroviral therapy). The second phase of the study, will quantify the impact of targeted Pre-Exposure Prophylaxis (PrEP) in the context of universal treatment and streamlined care. The study intervention is designed to improve the entire continuum of care, to reduce structural barriers for all populations including those most "at risk".

Conditions

• HIV
• Tuberculosis
• Hypertension
• Diabetes
• Maternal Child Health
• Cost Effectiveness

Interventions

OTHER

Universal ART in a streamlined care model

immediate ART start for all HIV+ in community with streamlined care

OTHER

Annual Community Health Campaigns

HIV and multi-disease testing for all community members

OTHER

Targeted PrEP and Targeted testing interventions

OTHER

Baseline community-based HIV and multi-disease testing

HIV and multi-disease testing for all community members at baseline only

Sponsors & Collaborators

• Infectious Diseases Research Collaboration, Uganda

  collaborator OTHER

• Makerere University

  collaborator OTHER

• Kenya Medical Research Institute

  collaborator OTHER

• Gilead Sciences

  collaborator INDUSTRY

• World Bank

  collaborator OTHER

• National Institute of Allergy and Infectious Diseases (NIAID)

  collaborator NIH

• United States President's Emergency Plan for AIDS Relief

  collaborator FED

• Bill and Melinda Gates Foundation

  collaborator OTHER

• University of California, San Francisco

  lead OTHER

Principal Investigators

• Diane Havlir, MD · University of California, San Francisco

• Moses Kamya, MBChB, PhD · Makerere University

• Maya Petersen, PhD · University of California, Berkeley

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

PARALLEL

Eligibility

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-04-30

Primary Completion

2021-04-30

Completion

2021-04-30

Countries

• Kenya
• Uganda