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Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes

NCT01804439 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 2240000

Last updated 2013-03-05

No results posted yet for this study

Summary

Cardiovascular disease (CVD) is an important public health problem that affects millions of people worldwide. Associations between risk factors, such as smoking, dyslipidaemia or hypertension, and prevalent CVD are well documented. However, few studies have investigated associations with onset of disease. The initial manifestation of CVD, for example an episode of unstable angina, is important because it influences the prognosis, the quality of life and the management of disease. Furthermore, the extent to which social deprivation, alcohol consumption or atrial fibrillation affects presentation of CVD is poorly understood and deserves further consideration.

Most previous studies have considered CVD as a single entity. However, differences in aetiology between coronary phenotypes suggest that risk factors may not be shared across specific coronary phenotypes and their relative importance is likely to differ for each phenotype. Gaining knowledge of these differences could provide insights into the pathophysiology of specific forms of CVD and could eventually lead to modification of recommendations for patient management and disease prevention.

We propose to use the linkage of the national registry of coronary events to general practice records in the Clinical Practice Research Database (CPRD), to investigate whether demographic, behavioral, and clinico-metabolic risk factors differentially influence the onset of specific types of CVD.

Conditions

  • Heart Diseases
  • Cardiovascular Diseases
  • Acute Myocardial Infarction
  • Unstable Angina
  • Chronic Stable Angina
  • Ischemic Stroke
  • Cerebrovascular Accident
  • Subarachnoid Hemorrhage
  • Transient Ischemic Attack
  • Abdominal Aortic Aneurysm
  • Peripheral Arterial Disease
  • Sudden Coronary Death
  • Ventricular Arrhythmia
  • Sudden Death
  • Cardiac Arrest
  • Heart Failure

Sponsors & Collaborators

  • University College, London

    lead OTHER

Eligibility

Min Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1997-01-31
Primary Completion
2010-03-31
Completion
2010-03-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01804439 on ClinicalTrials.gov