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Efficacy of Online Hemodiafiltrationlysis in Cytokine Removal

NCT01791712 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 28

Last updated 2013-02-15

No results posted yet for this study

Summary

Following the concept of "peak concentration hypothesis", which suggest the cutting peak of pro- and anti-inflammatory mediators would result in restoring a situation of immunohomeostasis. The investigators conducted the prospective randomized controlled trial aimed to compare the clearance efficacy between on-line hemodiafiltration and high-flux hemodialysis in sepsis-related acute kidney injury patients. The lowering cytokines level during sepsis is postulated to improved outcomes in sepsis.

Conditions

Interventions

PROCEDURE

On-line hemodiafiltration

pre-dilution 40% of blood flow rate blood flow rate 300-350 ml/min dialysate flow rate 800 ml/min

PROCEDURE

High-flux Hemodialysis

blood flow rate 300-350 ml/min dialysate flow rate 800 ml/min

Sponsors & Collaborators

  • Chulalongkorn University

    lead OTHER

Principal Investigators

  • Khajohn Tiranathanagul, M.D. · Chulalongkorn University

  • Wiwat Chancharoenthana, M.D. · Chulalongkorn University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-01-31
Primary Completion
2011-10-31
Completion
2011-10-31

Countries

  • Thailand

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01791712 on ClinicalTrials.gov