Supraspinal Control of Lower Urinary Tract Function in Healthy Controls and Patients With Bladder Dysfunction

Summary

The purpose of this study is to provide profound insight into the supraspinal neuronal mechanisms and networks responsible for lower urinary tract (LUT) control and to verify, amend or adjust neuronal circuitry models established from findings in healthy subjects in the context of neurogenic and non-neurogenic LUT dysfunction.

Conditions

• Neurogenic Lower Urinary Tract Dysfunction
• Multiple Sclerosis
• Overactive Bladder
• Spinal Cord Injury

Interventions

OTHER

fMRI

2 measurements using functional magnetic resonance imaging in a 3T scanner

OTHER

bladder filling

Repetitive retrograde bladder filling via transurethral catheter with different filling volumes using body warm saline during each of the fMRI measurements.

OTHER

bladder cooling

Retrograde bladder filling via transurethral catheter with 4-8°C saline during each of the fMRI measurements.

OTHER

additional post-treatment fMRI scan

Should NNOAB or SCI patients receive a study independent OAB therapy by their treating physician after the 2nd fMRI scan, they will be invited for an additional third fMRI scan.

Sponsors & Collaborators

• Swiss National Science Foundation

  collaborator OTHER

• Balgrist University Hospital

  collaborator OTHER

• University of Zurich

  lead OTHER

Principal Investigators

• Ulrich Mehnert, MD · Neuro-Urology, Spinal Cord Injury Center & Research, University of Zurich, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, Switzerland

• Thomas M Kessler, MD · Neuro-Urology, Spinal Cord Injury Center & Research, University of Zurich, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, Switzerland

• Spyros Kollias, MD · Institute of Neuroradiology, University Hospital Zurich, Sternwartstrasse 6, 8091 Zurich, Switzerland

Study Design

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2011-12-31

Primary Completion

2015-07-17

Completion

2018-12-31

Countries

• Switzerland

Study Locations