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Pancreatic Exocrine Insufficiency and Pancreatic Enzyme Supplementation in Critically Ill Adult Patients

NCT01753024 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 362

Last updated 2018-09-06

No results posted yet for this study

Summary

Malnutrition is a frequent problem in critically ill patients that is associated with detrimental clinical outcomes. To provide adequate nutritional support, current studies focused mostly on the choice of delivery timing, formula selection and the route of administration, little attention was paid to malnutrition related to exocrine pancreatic insufficiency (EPI).

In fact, malnutrition is also a major consequence of pancreatic exocrine insufficiency and pancreatic damage is commonly observed in critically ill patients without prior pancreatic diseases. Hence, EPI associated malnutrition should be concerned due to the high prevalence of pancreatic damage in critically ill patients.

The aims of this study is to evaluate the incidence of EPI in critically ill adult patients and explore its potential risk factors. Moreover, the efficacy of pancreatic enzyme supplementation therapy on malnutrition in ICU patients with specific clinical characteristics will be investigated.

Conditions

  • Critical Illness
  • Sepsis
  • Diabetes
  • Cardiac Arrest
  • Acute Renal Failure
  • Shock

Interventions

DIETARY_SUPPLEMENT

Enteral nutrition (EN)

All patients enrolled in this study must carry out nutritional support by enteral nutrition

Sponsors & Collaborators

  • Tongji Hospital

    collaborator OTHER

  • Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

    collaborator OTHER

  • Shanghai 10th People's Hospital

    lead OTHER

Principal Investigators

  • Sheng Wang, MD, PhD · Shanghai 10th People's Hospital

  • Yu G Zhuang, MD, MSc · Shanghai 10th People's Hospital

  • Li J Ma, MD, MSc · Shanghai 10th People's Hospital

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-01-31
Primary Completion
2015-12-31
Completion
2015-12-31

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01753024 on ClinicalTrials.gov