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Norwegian Intensive Care Unit Dalteparin Effect Study

NCT01721928 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 70

Last updated 2017-12-12

No results posted yet for this study

Summary

The main purpose of the NORIDES study is to investigate the effect of pharmacological thromboprophylaxis with low molecular weight heparins (LMWHs) in critically ill patients, and how it is affected by presence of acute kidney injury (AKI) and treatment with hemodialysis. The main objective is to compare the prophylactic effect of dalteparin in intensive care unit (ICU) patients with AKI and Citrate-Calcium dialysis (CiCa-dialysis) with a control group of ICU patients with normal kidney function. Our main hypothesis is that CiCa-dialysis reduces dalteparin effect, and that patients undergoing CiCa-dialysis do not achieve adequate prophylaxis against venous thromboembolism (VTE). The primary endpoint is development of DVT during ICU stay, the secondary endpoint inadequate heparin effect measured in blood samples.

Conditions

Interventions

DEVICE

Continuous venovenous hemodialysis

Continuous venovenous hemodialysis

Sponsors & Collaborators

  • University of Oslo

    collaborator OTHER

  • Oslo University Hospital

    lead OTHER

Principal Investigators

  • Kjetil Sunde, Professor · Oslo University Hospital

  • Sigrid Beitland, MD · Oslo University Hospital

  • Per M Sandset, Professor · Oslo University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-12-03
Primary Completion
2016-06-02
Completion
2017-03-01

Countries

  • Norway

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01721928 on ClinicalTrials.gov