Reperfusion Treatment in Acute Pulmonary Embolism

Summary

International guidelines recommend immediate reperfusion with systemic thrombolysis (ST) as first-line treatment in high-risk pulmonary embolism (PE). The therapy improves hemodynamics and overall survival but is also associated with a significant risk of severe bleeding. Catheter-directed intervention (CDI) is recommended as an alternative reperfusion therapy in high-risk PE when ST is contraindicated or has failed, as well as in patients who deteriorate or fail to improve during anticoagulation (AC) treatment. Despite lack of high-quality evidence and randomized studies between CDI and standard care, the use of CDI is spreading rapidly in high-risk PE and in less severe PE not fulfilling current treatment criteria.

Conditions

• Pulmonary Embolism

Interventions

PROCEDURE

Catheter directed intervention, any device

Catheter directed intervention for treatment of pulmonary embolism

DRUG

Alteplase

Systemic thrombolysis

Sponsors & Collaborators

• Stockholm South General Hospital

  collaborator OTHER

• Karolinska University Hospital

  collaborator OTHER

• Danderyd Hospital

  collaborator OTHER

• University Hospital, Linkoeping

  collaborator OTHER

• Sunderby Hospital

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• Örebro University, Sweden

  collaborator OTHER

• Odense University Hospital

  collaborator OTHER

• Skane University Hospital

  collaborator OTHER

• Rigshospitalet, Denmark

  collaborator OTHER

• Sahlgrenska University Hospital

  lead OTHER

Principal Investigators

• Kristina Svennerholm, Assoc Prof · Sahlgrenska University Hospital

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-04-01

Primary Completion

2028-05-01

Completion

2029-05-01

Countries

• Denmark
• Sweden

Study Locations