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Diagnostic Study of Biomarkers in BAL of ICU Patients With Lung Infiltrates

NCT01695499 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2020-04-20

No results posted yet for this study

Summary

The aim of this project is therefore to explore on the clinical significance of analyzing surrogate markers combined with conventional diagnostics in the ICU setting. BAL, blood and biopsy samples will be subjected to a combined analysis of GM, BDG, Aspergillus specific PCR assays in addition to conventional diagnostics (Microscopy, Culture,Histology) for ICU pts with pulmonary infiltrates.

As GM and BDG are not species-specific, three established and repeatedly published species specific PCR-based assays (nested PCR, real time PCR assay, multifungal DNA Array)developed by our group will be investigated in combination with the serological tests in a multicenter prospective clinical diagnostic trial.

Conditions

  • INvasive Aspergillosis
  • Mechanical Ventilation
  • Lung Infiltrates
  • Diagnostics
  • Biomarker

Sponsors & Collaborators

  • Pfizer

    collaborator INDUSTRY

  • Heidelberg University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-08-31
Primary Completion
2020-12-31
Completion
2020-12-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01695499 on ClinicalTrials.gov