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Non-invasive Diagnosis of Invasive Pulmonary Aspergillosis by Use of Biomarkers in Exhaled Breath Condensate

NCT04358419 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 101

Last updated 2024-02-13

No results posted yet for this study

Summary

In this study, a new, non-invasive method for diagnosis of pulmonary aspergillosis (PA) will be tested in a clinical pilot project.

Conditions

  • Aspergillosis Pneumonia
  • Pneumocystis Pneumonia

Interventions

DIAGNOSTIC_TEST

Aspergillus specific proteins in exhaled breath condensate (EBC)

The EBC will be collected by use of the RTube(R) system which is commercially available for the purpose of collection of EBC. As the patient breathes through a mouth piece, the exhaled breath is lead through a cooling chamber where the vaporous part of the exhaled breath condenses. The investigators aim at collecting a total minimum of 3.0 mL EBC per study participant in order to have sufficient amount of protein for the subsequent analysis.

DIAGNOSTIC_TEST

Pneumocystis jirovecii DNA in exhaled breath condensate (EBC)

The EBC will be collected by use of the RTube(R) system which is commercially available for the purpose of collection of EBC. As the patient breathes through a mouth piece, the exhaled breath is lead through a cooling chamber where the vaporous part of the exhaled breath condenses. The investigators aim at collecting a total minimum of 3.0 mL EBC per study participant in order to have sufficient amount of protein for the subsequent analysis.

Sponsors & Collaborators

  • Aarhus University Hospital

    collaborator OTHER

  • Inger Lise Gade

    lead OTHER

Principal Investigators

  • Inger L Gade, MD PhD · Aalborg University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-04-17
Primary Completion
2023-12-31
Completion
2023-12-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04358419 on ClinicalTrials.gov