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Regulation of Tissue Lipolysis by Insulin in Type 2 Diabetes

NCT01680133 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2012-10-12

No results posted yet for this study

Summary

Inadequate suppression of intramuscular and adipose tissue lipolysis, and consequent excessive delivery of fatty acids to ectopic tissues (e.g. muscle, pancreas and liver) could play an important role in the development and exacerbating of insulin resistance. Therefore, the investigators propose to study the regulation of adipose tissue and skeletal muscle lipolysis, as well as further characterize the intracellular lipolytic pathways within these tissues, in obese normoglycaemic versus long-term diagnosed type 2 diabetic subjects.

Conditions

Interventions

OTHER

Hyperinsulinemic euglycemic clamp

Sponsors & Collaborators

  • Netherlands Organisation for Scientific Research

    collaborator OTHER_GOV

  • European Foundation for the Study of Diabetes

    collaborator OTHER

  • Maastricht University Medical Center

    lead OTHER

Principal Investigators

  • Ellen Blaak, PhD · Maastricht University Medical centre

Eligibility

Min Age
45 Years
Max Age
65 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-06-30
Primary Completion
2011-09-30
Completion
2011-09-30

Countries

  • Netherlands

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01680133 on ClinicalTrials.gov