Regional Lipolysis Insulin Regulation
NCT06392854 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 48
Last updated 2026-04-13
Summary
Adults who gain most of their excess weight in the abdominal area typically do not respond to insulin in the same way as lean adults. Researchers are trying to understand why fat tissue responds differently in people with different body types.
Conditions
Interventions
- DRUG
-
2 dose insulin infusion 4 hours
Sponsors & Collaborators
-
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
collaborator NIH - lead OTHER
Principal Investigators
-
Michael Jensen, MD · Mayo Clinic
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- BASIC_SCIENCE
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2024-05-01
- Primary Completion
- 2028-06-30
- Completion
- 2028-06-30
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Avoidance of Insulin-induced Lipohypertophy in People With Diabetes Using Ultrasound Scanning Within Diabetes Clinics
NCT06782568 ·Status: RECRUITING ·Phase: NA
-
The Effect of Liraglutide on Dietary Lipid Induced Insulin Resistance in Humans
NCT02403284 ·Status: COMPLETED ·Phase: PHASE4
-
Influence of Central Nervous Insulin Action on Insulin Sensitivity of Peripheral Organs in Lean Versus Overweight Humans
NCT02468999 ·Status: COMPLETED ·Phase: NA
-
The Role of the Duodenum in the Pathogenesis of Insulin Resistance and Type 2 Diabetes Mellitus
NCT00568620 ·Status: COMPLETED ·Phase: NA
-
GLP-1 Therapy: The Role of IL-6 Signaling and Adipose Tissue Remodeling in Metabolic Response
NCT04387201 ·Status: COMPLETED ·Phase: PHASE4
-
The Effects of Glucagon on Hepatic Metabolism
NCT05500586 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Trial of Leptin Replacement Therapy in Patients With Lipodystrophy
NCT00896298 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Effects of GLP1-RA on Ectopic Fat Deposition in Chronic Kidney Disease
NCT05254418 ·Status: COMPLETED ·Phase: PHASE2
-
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
NCT06967558 ·Status: RECRUITING ·Phase: PHASE2
-
Location of GLP-1 Release
NCT02036710 ·Status: COMPLETED
-
Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1 Diabetes Mellitus
NCT05985135 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
The Effect of Liraglutide Treatment on Postprandial Chylomicron and VLDL Kinetics, Liver Fat and de Novo Lipogenesis
NCT02765399 ·Status: COMPLETED ·Phase: PHASE4
-
Recombinant Human Leptin Therapy Effects on Insulin Action
NCT01207934 ·Status: COMPLETED ·Phase: NA
-
GLP-1 Response and Effect in Individuals With Obesity Causing Genetic Mutations
NCT02082496 ·Status: COMPLETED ·Phase: PHASE2
-
The Effect of rs7903146 Genotype on Islet GLP-1 Production in Humans
NCT06972407 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Targeting Beta-cell Failure in Lean Patients With Type 2 Diabetes
NCT04657939 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Oral Semaglutide on Liver Fat and Body Composition in Liver Transplant Recipients With Diabetes Mellitus
NCT06060392 ·Status: RECRUITING ·Phase: NA
-
The Contribution of Incretin Hormones to the Amelioration of Glucose Metabolism After Roux-en-Y Gastric Bypass
NCT01843855 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Cardiovascular Effects of GLP-1 Receptor Activation
NCT03101930 ·Status: COMPLETED ·Phase: PHASE4
-
Incretin Effect in Lean and Obese Subjects
NCT00803296 ·Status: COMPLETED
-
A Study to Examine the Effects of the Leptin Receptor (LEPR) Agonist Antibody REGN4461 in Adult Patients With Familial Partial Lipodystrophy (FPLD)
NCT05088460 ·Status: TERMINATED ·Phase: PHASE2
-
Leptin to Treat Lipodystrophy
NCT00005905 ·Status: COMPLETED ·Phase: PHASE2
-
SGLTi, Hepatic Glucose Production and Ketogenesis
NCT05960656 ·Status: RECRUITING ·Phase: PHASE1
-
GLP-1 and Hypoglycemia
NCT01858896 ·Status: ACTIVE_NOT_RECRUITING ·Phase: EARLY_PHASE1
-
Lypo-hypertrofia Characterization in Diabetes
NCT02278926 ·Status: COMPLETED