Building Research Initiative Group: Chronic Illness Management and Adherence in Transplantation

Summary

Over the past decades, survival rates in heart transplantation recipients improved significantly, due to advancements in regimens of immunosuppressives and surgical techniques, but are still limited to the first 12 months post transplantation. Long-term survival remains almost unchanged indicating the need to identify and improve relevant factors. Evidence in other chronically-ill patient populations shows that the healthcare system (e.g. level of chronic illness management (CIM)) and patient self-management (e.g. adherence) drive improvements in outcomes.

The BRIGHT study is the first multi-centre, multi-continental study examining healthcare system and heart transplant centres chronic illness management practice patterns and potential correlates of immunosuppressive medication nonadherence.

The knowledge gained will inform clinicians, researchers and healthcare policy makers about the level(s) interventions need to be implemented at to improve long-term outcomes for transplant recipients.

Conditions

• Heart Transplantation

Sponsors & Collaborators

• KU Leuven

  collaborator OTHER

• University of Missouri, Kansas City

  collaborator OTHER

• Universitaire Ziekenhuizen KU Leuven

  collaborator OTHER

• Hospital Universitario À Coruña, Spain

  collaborator UNKNOWN

• Azienda Ospedaliero, Universitaria Pisana

  collaborator OTHER

• Hannover Medical School

  collaborator OTHER

• Johns Hopkins University

  collaborator OTHER

• US Department of Veterans Affairs

  collaborator FED

• George Washington University

  collaborator OTHER

• Cliniques universitaires Saint-Luc- Université Catholique de Louvain

  collaborator OTHER

• Hopital Louis Pradel

  collaborator OTHER

• Hôpital Nord Laennec, France

  collaborator UNKNOWN

• Groupe Hospitalier Pitie-Salpetriere

  collaborator OTHER

• University Hospital Heidelberg

  collaborator OTHER

• University Hospital, Udine, Italy

  collaborator OTHER

• University of Bologna

  collaborator OTHER

• Hospital de Sant Pau

  collaborator OTHER

• Puerta de Hierro University Hospital

  collaborator OTHER

• Hospital Universitario La Fe

  collaborator OTHER

• Hospital Universitario Reina Sofia de Cordoba

  collaborator OTHER_GOV

• Insel Gruppe AG, University Hospital Bern

  collaborator OTHER

• University Hospital, Zürich

  collaborator OTHER

• Papworth Hospital NHS Foundation Trust

  collaborator OTHER_GOV

• Freeman Hospital, UK

  collaborator UNKNOWN

• Royal Brompton & Harefield NHS Foundation Trust

  collaborator OTHER

• Toronto General Hospital

  collaborator OTHER

• University of Ottawa Heart Institute, Canada

  collaborator UNKNOWN

• St. Paul's Hospital, Canada

  collaborator OTHER

• London Health Sciences Centre

  collaborator OTHER

• Duke University Hospital, USA

  collaborator UNKNOWN

• Virginia Commonwealth University

  collaborator OTHER

• The Cleveland Clinic

  collaborator OTHER

• Cedars-Sinai Medical Center

  collaborator OTHER

• Kaiser Permanente

  collaborator OTHER

• St Luke's Hospital, USA

  collaborator UNKNOWN

• Hospital of the University of Pennsylvania, USA

  collaborator UNKNOWN

• Ochsner Health System

  collaborator OTHER

• Hospital Israelita Albert Einstein

  collaborator OTHER

• Instituto Dante Pazzanese de Cardiologia

  collaborator OTHER

• Instituto do Coração da Universidade de São Paulo, Brazil

  collaborator UNKNOWN

• St Vincent's Hospital, Sydney

  collaborator OTHER

• The Prince Charles Hospital

  collaborator OTHER_GOV

• Astellas Pharma Europe Ltd., UK

  collaborator UNKNOWN

• University of Basel

  lead OTHER

Principal Investigators

• Sabina M De Geest, PhD, RN · University of Basel

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-03-31

Primary Completion

2015-10-31

Completion

2020-12-31

Countries

• Belgium

Study Locations