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Seroepidemiologic Study of Spermatozoal Transmission of Hepatitis B Virus (HBV)

NCT01574521 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 407

Last updated 2012-04-10

No results posted yet for this study

Summary

Animal experiments demonstrated that father might transmit HBV vertically via male germ line, however, whether it is really existed in human remains to be determined. Since HBV is a blood-borne virus, the unvaccinated pregnant women would be at risk for HBV exposure if their fetuses carried the virus from fathers. If women had been vaccinated for HBV before conception, what would happen to a maternal immune system if her fetus carried HBV from spermatozoa? However, the literature on transmission of HBV by spermatozoa in vivo is rare, the viral replicating status and fetal immune response in uterus are unknown. The aim of study was to detect father-to-fetus transmission of hepatitis B virus (HBV) in uterus.

Conditions

Sponsors & Collaborators

  • YiYang Zhu

    lead OTHER

Principal Investigators

  • Yi-Yang Zhu, MD · Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University

Eligibility

Min Age
16 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-01-31
Primary Completion
2010-12-31
Completion
2011-12-31

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01574521 on ClinicalTrials.gov