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Ventilation Strategies, Anesthetic Techniques and Cerebral Oxygenation in the Beach Chair Position

NCT01535274 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 67

Last updated 2022-04-06

Study results available
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Summary

The seated or "beach chair" position during surgery and general anesthesia decreases brain oxygen levels and can result in stroke. As such, poor neurological outcome following beach chair positioning is a growing concern. In the proposed study the investigators test the hypothesis that changes in ventilation strategy and anesthetic technique can affect cerebral oxygenation in anesthetized patients in the beach chair position.

Conditions

Interventions

OTHER

Inspired oxygen fraction / end tidal carbon dioxide

Following induction of anesthesia, FIO2 and minute ventilation will be sequentially adjusted to achieve: 1. FIO2 30% (70% nitrogen), PETCO2 30mmHg - supine position. 2. FIO2 30% (70% nitrogen), PETCO2 30mmHg - beach chair position. 3. FIO2 100%, PETCO2 30mmHg - beach chair position. 4. FIO2 100%, PETCO2 45mmHg - beach chair position. 5. FIO2 30% (70% nitrogen), PETCO2 30mmHg - beach chair position.

Sponsors & Collaborators

Principal Investigators

  • Paul Picton, MD · University of Michigan

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-09-30
Primary Completion
2014-09-30
Completion
2014-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01535274 on ClinicalTrials.gov