Ventilator Associated Pneumonia in Taper Guard Versus Normal Tube in ICU Patients

Summary

Ventilator associated pneumonia ( VAP) adds burden to the care of the intensive care patients as they may cause the death of the patient or prolong the intensive care stay or complicate the illness in other ways. The risk of infection is dependent on the interplay between bacteria load into the lungs and the immune status. There has been a lot of focus on bacteria load reduction and this includes the use of subglottic suctioning in an attempt to reduce the amount of bacteria that may move into the lungs. The Hi Lo tubes which were designed to allow subglottic suctioning was significantly effective in reducing the incidence of ventilator associated pneumonia compared to normal tubes. A new generation of endotracheal tubes that not only incorporate subglottic suctioning but provide a more snug fit into the tracheal by a new tapering design may be even more useful to provide the solution for bacterial load reduction. Conventional tubes which may furrow on themselves to allow the creation of microchannels may aid microaspiration. The taper guard which has facilities for subglottic suctioning as well as the strategy to reduce furrowing to the minimum may be the answer to the problem of ventilator associated pneumonia. This study is to determine the extent of protection this tube has against ventilator associated pneumonia compared with conventional endotracheal tubes

Conditions

• Ventilator Associated Pneumonia

Interventions

DEVICE

Taper Guard Endotracheal Tube

comparison of two different endotracheal tubes

OTHER

Conventional endotracheal tube

Sham Comparator

Sponsors & Collaborators

• University of Malaya

  lead OTHER

Principal Investigators

• Yoo-Kuen Chan, FFARCSI · Department of Anesthesiology, Faculty of Medicine, University of Malaya

• Vineya Rai, MAnesth; EDIC · Department of Anesthesiology, Faculty of Medicine, University of Malaya

• Mohd Shahnaz Hassan, MBBS;MAnesth · Department of Anesthesiology, Faculty of Medicine, University of Malaya

• Suresh Venogobal, MBBS; FANZCA · Department of Anesthesiology, Faculty of Medicine, University of Malaya

• Kang-Kwong Wong, MBBS;MAnesth · Department of Anesthesiology, Faculty of Medicine, University of Malaya

• Mohd Yasim Yusof, MBBS;MSc Microbiology · Department of Microbiology, Faculty of Medicine, University of Malaya

• Foong-Ming Moy, BSc, MSc, MMedSc PH, PhD · Julius Centre University of Malaya, Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya.

• Nur Adura Yaakup, MBBS, MRad · Department of Biomedical Imaging, Faculty of Medicine, University of Malaya

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-02-29

Primary Completion

2013-07-31

Completion

2013-12-31

Countries

• Malaysia

Study Locations