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Blood Pressure and Brain Blood Flow Regulation After Midodrine Administration in Those With Spinal Cord Injury

NCT01498809 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 22

Last updated 2019-10-01

No results posted yet for this study

Summary

This project aims to evaluate the physiological effects of Midodrine administration during orthostatic challenge in those with high level spinal cord injury. Midodrine has been shown to improve orthostatic symptoms in those with spinal cord injury but the physiological mechanisms influenced have not been identified. The investigators will examine key physiological components influencing orthostatic tolerance. The investigators will do this, by measuring the baroreflex, and brain blood flow autoregulation (the ability to maintain brain blood flow) before during and after the sit-up test. Two sit-up tests will occur; one before Midodrine administration, and one after administration of a 10mg dose of Midodrine.

Conditions

  • Orthostatic Intolerance

Interventions

DRUG

Midodrine

Single 10 mg dose

Sponsors & Collaborators

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Darren Warburton, PhD · University of British Columbia

  • Andrei Krassioukov, MD PhD · GF Strong Hospital University of British Columbia

Eligibility

Min Age
18 Years
Max Age
49 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-03-31
Primary Completion
2013-11-30
Completion
2013-11-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01498809 on ClinicalTrials.gov