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Neutrophil Extracellular Traps Formation Post-hematopoietic Stem Cell Transplantation

NCT01491230 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2011-12-13

No results posted yet for this study

Summary

Identifying the post-transplantation phase wherein neutrophils recover their ability to release NETs could shed new light on the mechanism responsible for the increased susceptibility to infection among these patients and aid in improving their prophylactic antimicrobial treatment. Therefore, we aim to examine neutrophil extracellular traps (NETs) formation, in relation to other neutrophil functions like chemotaxis, superoxide production, hydrogen peroxide production, and the presence of myeloperoxidase, in pediatric patients undergoing autologous and allogeneic hematopoietic stem cell transplantation (HSCT).

Conditions

  • Childhood Cancer

Sponsors & Collaborators

  • Max Planck Institute for Infection Biology

    collaborator OTHER

  • Meir Hospital, Kfar Saba, Israel

    collaborator OTHER

  • Tel-Aviv Sourasky Medical Center

    lead OTHER_GOV

Principal Investigators

  • Sivan Achituv, MD · Tel-Aviv Sourasky Medical Center

Eligibility

Max Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-12-31
Primary Completion
2014-12-31
Completion
2014-12-31

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01491230 on ClinicalTrials.gov