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Analgesic Effect of Escitalopram in Total Knee Arthroplasty (TKA)

NCT01430520 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2013-06-05

No results posted yet for this study

Summary

Pain is a major problem after TKA, especially in patients with high pain catastrophizing. Newer MR-scan studies indicate that Escitalopram may have an immediate cognitive and emotional effect. The investigators therefore investigate the effect of Escitalopram as a perioperative analgesic.

Conditions

  • Postoperative Pain

Interventions

DRUG

Escitalopram

Tables with Escitalopram (10 mg), 1 tablet a day for 7 days, starting on the day of surgery

DRUG

Placebo

Placebo tablets, 1 tablet a day for 7 days, starting on the day of surgery

Sponsors & Collaborators

  • Lundbeck Foundation

    collaborator OTHER

  • Hvidovre University Hospital

    lead OTHER

Principal Investigators

  • Torben B Hansen, MD · Regionshospitalet Holstebro

  • Henrik Kehlet, MD · Rigshospitalet, Denmark

  • Per W Kristensen, MD · Vejle Sygehus

  • Søren Solgaard, MD · Gentofte Hospital

  • Vibe G Frøkjær, MD · Rigshospitalet, Denmark

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-09-30
Primary Completion
2013-04-30
Completion
2013-05-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01430520 on ClinicalTrials.gov