Epidemiology Study of Psychosis

Summary

Purpose Psychotic disorders (including schizophrenia) are complex neurobehaviour disorders influenced by genetic, neurodevelopmental, neurochemical, as well as psychosocial factors. Despite significant progresses in pharmacotherapy, the disorder often results in long-term disability (ranked globally amongst the top ten leading causes of disability-adjusted life years, DALYS), often associated with extensive cost, burden, morbidity and mortality.

Objective / hypothesis The study aims to (1) measure the prevalence of psychotic symptoms in the Hong Kong population; (2) explore associated risk and protective factors for the expression of psychotic symptoms; (3) characterize the functional disability in people with psychotic symptoms; and (4) study the determinant of clinical presentation or non-presentation in people with psychotic symptoms.

Design, subjects and study instrument The survey will be conducted with a two-phase design. The first phase interviews will include approximately 5,000 subjects with structured assessments serving diagnostic criteria for CMD, screening instruments for psychotic disorder, substance misuse and suicidal behaviours, functioning, service use and demographics. The second phase comprises of clinician interviews for psychotic disorder and "at risk mental state" and other variables including neurocognitive, help seeking, stigma and well-being.

Analysis Prevalence estimates will be weighted, expressed as rates and confidence intervals. Comorbidity will be estimated using Latent Class Analysis (LCA) Logistic regression will be used to identify significant factors associated with mental disorders.

Conditions

• Psychotic Disorders

Sponsors & Collaborators

• Queen Mary Hospital, Hong Kong

  collaborator OTHER

• Kowloon Hospital, Hong Kong

  collaborator OTHER

• Castle Peak Hospital

  collaborator OTHER_GOV

• North District Hospital, Hong Kong

  collaborator UNKNOWN

• Shatin Hospital

  collaborator OTHER

• Tai Po Hospital

  collaborator OTHER_GOV

• Kwai Chung Hospital

  collaborator OTHER

• Prince of Wales Hospital, Shatin, Hong Kong

  collaborator OTHER

• The University of Hong Kong

  lead OTHER

Principal Investigators

• May Mei-ling LAM, MBBS · The University of Hong Kong

Eligibility

Min Age

16 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2010-08-31

Primary Completion

2013-08-31

Completion

2013-12-31

Countries

• China

Study Locations