Effectiveness of Antipsychotic Combination With Psychosocial Intervention on Outcome of Patients With Schizophrenia

Summary

Antipsychotic alone is limit to improve the overall outcome of schizophrenia and has a high discontinue rate.To solve these problems, we provide practical and available psychosocial intervention. We hypothesize that there will be significant difference in the overall effectiveness between antipsychotic and antipsychotic combination with psychosocial intervention.

Conditions

• Schizophrenia

Interventions

DRUG

Chlorpromazine, Sulpiride, Clozapine, Olanzapine, Risperidone, Quetiapine, Aripitrazole

patient will receive one of the seven study drugs (Chlorpromazine, Sulpiride, Clozapine, Olanzapine, Risperidone, Quetiapine, Aripitrazole) as the maintain treatment. the dose is flexible, is based on the study doctor's judgment.

BEHAVIORAL

psychosocial intervention

the psychosocial interventions include psychoeducaiton, family intervention, skill training, and cognitive-behavioral therapy.

Sponsors & Collaborators

• Shanghai Mental Health Center

  collaborator OTHER

• Sichuan University

  collaborator OTHER

• Capital Medical University

  collaborator OTHER

• Nanjing Medical University

  collaborator OTHER

• Jiangxi Mental Hospital

  collaborator UNKNOWN

• Hunan Mental Hospital

  collaborator OTHER

• Guangzhou Mental Hospital

  collaborator OTHER

• Chongqing Metal Institute

  collaborator UNKNOWN

• Henan Mental Hospital

  collaborator UNKNOWN

• Central South University

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

FACTORIAL

Eligibility

Min Age

16 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2005-02-28

Primary Completion

2007-12-31

Completion

2007-12-31

Countries

• China

Study Locations