Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With Uterine Cancer

Summary

This pilot clinical trial studies radiation therapy, paclitaxel, and carboplatin in treating patients with uterine cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or stopping them from dividing. Giving radiation with chemotherapy may kill more tumor cells.

Conditions

• Stage IA Uterine Sarcoma
• Stage IB Uterine Sarcoma
• Stage IC Uterine Sarcoma
• Stage IIA Uterine Sarcoma
• Stage IIB Uterine Sarcoma
• Stage IIIA Uterine Sarcoma
• Stage IIIB Uterine Sarcoma
• Stage IIIC Uterine Sarcoma
• Stage IVA Uterine Sarcoma
• Stage IVB Uterine Sarcoma
• Uterine Carcinosarcoma

Interventions

DRUG

paclitaxel

Given IV

DRUG

carboplatin

Given IV

RADIATION

external beam radiation therapy

Undergo external beam radiation therapy

RADIATION

brachytherapy

Undergo HDR brachytherapy

RADIATION

intensity-modulated radiation therapy

Undergo IMRT

OTHER

laboratory biomarker analysis

Correlative studies

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Albert Einstein College of Medicine

  lead OTHER

Principal Investigators

• Merieme Klobocista · Albert Einstein College of Medicine

• Dennis Yi-Shin Kuo · Montefiore Medical Center

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-07-08

Primary Completion

2018-08-15

Completion

2018-08-15

Countries

• United States

Study Locations