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Natural History of HPV From Infection to Neoplasia in Adolescents and Young Women

NCT01366742 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 900

Last updated 2016-05-17

No results posted yet for this study

Summary

The natural history of human papillomavirus (HPV) is most likely influenced by both innate and adaptive mucosal immunity. More specifically, we hypothesize that Toll like receptors (TLR) play an important role in cervical innate immunity to HPV through secretions of proinflammatory, chemotactic and anti-viral cytokines. Up-regulated TLR expression will also result in activation of dendritic cells and T cells that in turn will promote a T helper (Th) l like response through secretion of several cytokines and consequently, the induction of a successful cell mediated immune (CMI) response.

Conditions

  • Human Papillomavirus
  • CIN 2
  • CIN 3

Sponsors & Collaborators

Principal Investigators

  • Anna-Barbara Moscicki, MD · University of California, San Francisco

Eligibility

Min Age
13 Years
Max Age
22 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1987-12-31
Primary Completion
2016-05-31
Completion
2016-05-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01366742 on ClinicalTrials.gov