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Intervention Study to Compare the Natriuretic Effects of Enalapril on Low and High Salt Diet

NCT01324245 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2011-03-28

No results posted yet for this study

Summary

The kidney plays a crucial role in maintaining salt balance by two opposing physiological mechanisms: the renal dopaminergic system which enhances salt excretion and the renin-angiotensin system (RAS) which causes salt retention. Salt-sensitive hypertension occurs when this balance is altered or abnormal. We hypothesized that this balance is influenced by salt intake: therefore dietary salt affects the natriuretic response to the renal dopaminergic agonist Fenoldopam, and the Angiotensin Converting Enzyme inhibitor, Enalapril.

In this trial we study normal salt balance mechanisms in salt resistant adults with normal blood pressure.

Conditions

  • Salt-sensitive Hypertension

Interventions

DRUG

Fenoldopam

Intravenous infusion at 0.5 mics/Kg/min for three hours

Sponsors & Collaborators

  • University of Virginia

    collaborator OTHER

  • Georgetown University

    lead OTHER

Principal Investigators

  • Aruna R Natarajan, MD, PhD · Georgetown University Hospital

  • Pedro A Jose, MD, PhD · Georgetown University/ George Washington University

Study Design

Allocation
RANDOMIZED
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2002-11-30
Primary Completion
2005-12-31
Completion
2006-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01324245 on ClinicalTrials.gov