MedTrace Logo

Prospective Phenotyping of Autonomous Aldosterone Secretion

NCT03484130 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-10-23

No results posted yet for this study

Summary

This prospective cohort study will investigate the physiology and progression of autonomous aldosterone secretion.

Conditions

  • Aldosterone Disorder
  • Adrenal Gland Disease
  • Blood Pressure

Interventions

DIETARY_SUPPLEMENT

Sodium loaded diet

At baseline, and annually, participants will undergo aldosterone dynamic testing after \~5 days of a sodium loaded diet. The diet will consist of \>180 mmol/day of sodium, \~50 mmol/day of potassium, and 600mg/d of calcium.

DIETARY_SUPPLEMENT

Restricted sodium diet

At baseline, and annually, participants will undergo aldosterone dynamic testing after \~5 days of a sodium restricted diet. The diet will consist of \<40 mmol/day of sodium, \~50 mmol/day of potassium, and 600mg/d of calcium.

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • Brigham and Women's Hospital

    lead OTHER

Principal Investigators

  • Anand Vaidya, MD, MMSc · Brigham and Women's Hospital

Eligibility

Min Age
35 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-06-15
Primary Completion
2026-04-01
Completion
2029-07-01

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03484130 on ClinicalTrials.gov