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Epidural Versus Patient-controlled Analgesia for Reduction in Long-term Mortality Following Colorectal Cancer Surgery

NCT01318161 · Status: TERMINATED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 221

Last updated 2021-02-16

No results posted yet for this study

Summary

Colorectal cancer is one of the most common cancers in the industrialized world (12% of all cancers). In Sweden, 6000 new cases of colorectal cancer are reported each year, and almost half of these cases result in death. Several recently published retrospective studies show that regional anaesthesia (RA) can reduce cancer-related mortality following surgical treatment of colorectal, breast and prostate cancers and malignant melanoma. If these results are true, then the choice of perioperative pain management is as beneficial, or even better, than the current oncological therapies. This theory needs to be investigated in a prospective, randomized and controlled trail.

Conditions

Interventions

DRUG

Ropivacaine + opioid epidurally

Epidural analgesia with local anesthetic + opioid

DRUG

Morphine

Morphine via PCA pump

Sponsors & Collaborators

  • University Hospital, Linkoeping

    collaborator OTHER

  • Örebro University, Sweden

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-03-31
Primary Completion
2020-12-31
Completion
2021-01-31

Countries

  • Sweden

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01318161 on ClinicalTrials.gov