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The Development Of A Novel Biomarker For Early Identification Of The Individual's State Of Tolerance To Heat

NCT01290159 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2013-12-19

No results posted yet for this study

Summary

Today, the level of tolerance to heat is based on physiological strain indices, with no correlates to any relevant biomarker. We hypothesize that oxidative stress (OS) and the formation of reactive oxygen and nitrogen species (ROS, RNS), which are part of the underling pathophysiology related to hyperthermia, can be used to identify tolerance/intolerance to heat. The aim of the present project is to develop a simple assay, based on specific designed sensitive biomarkers of OS that can be detected in a small blood sample, and to possibly correlate each individual's state of tolerance to heat to the level of OS. These biomarkers specially designed and synthesized to form a novel probe (not present as such in biological organs). The method will be based on the incubation of the suggested biomarkers with the patient's blood sample and the measurement of the level and type of oxidative alteration of the markers. For this goal, post heat stroke patients, with different levels of tolerance to heat and subjects during a process of acclimation to heat will be studied. Such a method will add to our ability to better determine the level of tolerance to heat and not rely only on the measurements of temperature and heart rate during an exercise-heat stress.

Conditions

  • Heat Stroke
  • Healthy

Interventions

OTHER

heat tolerance test (HTT)

An exercise-heat test,which consists of 120 min exposure to walking on a treadmill (5km/h; 2% grade) under conditions of 40oC and 50% rh.

Sponsors & Collaborators

  • Sheba Medical Center

    lead OTHER_GOV

Principal Investigators

  • Yoram Epstein, PhD · Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer

  • Amit Druyan, MD · Heller Institute of Medical Research, Sheba Medical Center

Eligibility

Min Age
18 Years
Max Age
28 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-05-31
Primary Completion
2013-04-30
Completion
2013-07-31

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01290159 on ClinicalTrials.gov