The Detection of Heat Stress by Assessing Individual Body Responses to Heat (Heat Strain) in Young and Healthy Non-athlete Participants

Summary

• This study investigates and compares the within and in-between variances of the body responses to different heat stressors in a controlled lab-setting. The participants will be exposed to different heat sources while a variety of physiological heat strain reactions such as heartrate, sweat rate, and core body temperature are recorded using on- and in-body devices. For the participant monitoring during the study, medical grade devices such as a certified ECG and a swallowable sensor-pill to continuously monitor the core body temperature will be applied. A one-for-all wearable device is additionally applied for physiological validation. Further, sweat will be collected to assess (i) the local sweat rate and (ii) the appearance of different heat stress associated molecular markers in this non-invasively collectable biofluid. As a secondary aim, a model will be developed that will enable to predict the different heat stress sources out of the heat strain measurements.

Conditions

• Heat Stress

Interventions

OTHER

Elevated ambient heat

Temporary exposure to increased ambient temperature +10°C (the effect of the intervention is fully and spontaneously reversible)

OTHER

Elevated relative humidity

Temporary exposure to increased ambient relative humidity +40% (max. 90%) (the effect of the intervention is fully and spontaneously reversible)

OTHER

Exertion

Temporary exertion on an ergometer (1W/kg body weight) (the effect of the intervention is fully and spontaneously reversible)

Sponsors & Collaborators

• Swiss Federal Office of Sports (BASPO)

  collaborator UNKNOWN

• University of Zurich

  collaborator OTHER

• Center for Chronobiology, Psychiatric University Clinics, Basel

  collaborator UNKNOWN

• epyMetrics

  collaborator UNKNOWN

• Innosuisse - Swiss Innovation Agency

  collaborator OTHER

• Swiss Federal Railways

  collaborator UNKNOWN

• ETH Zurich

  lead OTHER

Principal Investigators

• Noé Brasier, MD · ETH Zurich

Eligibility

Min Age

18 Years

Max Age

40 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-11-02

Primary Completion

2023-01-31

Completion

2023-02-10

Countries

• Switzerland

Study Locations