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Identification of Critical Thermal Environments for Aged Adults

NCT04284397 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 190

Last updated 2026-01-27

No results posted yet for this study

Summary

This study evaluates critical environmental limits (temperature and humidity) above which older adults are unable to effectively thermoregulate. Participants will exercise in a series of different environmental conditions to identify combinations of temperature and humidity above which age-related physiological changes cause uncompensable heat stress, resulting in increased risk of heat illness.

Conditions

  • Aging

Interventions

DRUG

Low dose ASA

A sub-group of older adults will be re-tested after 7 days of treatment with low-dose aspirin.

OTHER

Control

All participants will be tested with no treatment.

Sponsors & Collaborators

  • Penn State University

    lead OTHER

Principal Investigators

  • W. Larry Kenney, Ph.D. · The Pennsylvania State University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-12-30
Primary Completion
2027-02-27
Completion
2027-02-27
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04284397 on ClinicalTrials.gov