Impact of Thermal Stress on Pulmonary Absorption and Toxicokinetics of 3 Organic Solvents

Summary

In Quebec, thousands of workers are concomitantly exposed to heat and chemical compounds. Exposure to heat induces physiological responses that help maintaining a stable body temperature. Those changes can affect organ functions implicated in absorption and metabolism. According to literature, those changes could lead to increased concentrations of chemical compounds in the body and their toxicity. Therefore, the aim of this study is to evaluate the pulmonary absorption and toxicokinetics of 3 organic solvents in heat stress conditions in volunteers exposed in a inhalation chamber. Results will then be used to develop PBPK models that will allow to predict organic solvent kinetics when coexposed with heat.

Conditions

• Heat

Interventions

OTHER

Heat stress (21)

4h exposure to heat (WBGT of 21°C), no solvent

OTHER

Heat stress (25)

4h exposure to heat (WBGT of 25°C), no solvent

OTHER

Heat stress (30)

4h exposure to heat (WBGT of 30°C), no solvent

OTHER

Heat Stress (21) +TOL

4h exposure to heat (WBGT of 21°C) + Toluene (concentration = TLV)

OTHER

Heat stress (25) + TOL

4h exposure to heat (WBGT of 25°C) + Toluene (concentration = TLV)

OTHER

Heat stress (21) + TOL

4h exposure to heat (WBGT of 30°C) + Toluene (concentration = TLV)

OTHER

Heat stress (21) + ACE

4h exposure to heat (WBGT of 21°C) + Acetone (concentration = TLV)

OTHER

Heat stress (25) + ACE

4h exposure to heat (WBGT of 25°C) + Acetone (concentration = TLV)

OTHER

Heat stress (30) + ACE

4h exposure to heat (WBGT of 30°C) + Acetone (concentration = TLV)

OTHER

Heat stress (21) + DCM

4h exposure to heat (WBGT of 21°C) + Dichloromethane (concentration = TLV)

OTHER

Heat stress (25) + DCM

4h exposure to heat (WBGT of 25°C) + Dichloromethane (concentration = TLV)

OTHER

Heat stress (30) + DCM

4h exposure to heat (WBGT of 30°C) + Dichloromethane (concentration = TLV)

OTHER

Heat stress (21) + TOL (dermal)

4h exposure to heat (WBGT of 21°C) + Toluene (concentration = TLV), participants breath normal air through a mask for evaluation of dermal absorption.

OTHER

Heat stress (25) + TOL (dermal)

4h exposure to heat (WBGT of 25°C) + Toluene (concentration = TLV), participants breath normal air through a mask for evaluation of dermal absorption.

OTHER

Heat stress (30) + TOL (dermal)

4h exposure to heat (WBGT of 30°C) + Toluene (concentration = TLV), participants breath normal air through a mask for evaluation of dermal absorption.

Sponsors & Collaborators

• Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail

  collaborator OTHER

• Université de Montréal

  lead OTHER

Principal Investigators

• Sami Haddad, Ph.D · Université de Montréal

Study Design

Allocation

NA

Purpose

PREVENTION

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

50 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-11-30

Primary Completion

2016-08-31

Completion

2018-06-30

Countries

• Canada

Study Locations