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Chemoprevention of Prostate Cancer, HDAC Inhibition and DNA Methylation

NCT01265953 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 98

Last updated 2019-05-01

Study results available
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Summary

The objective of the study is to identify mechanisms by which compounds found in cruciferous vegetables alter gene expression via epigenetic modifications (changes in gene expression) and may prevent prostate cancer development.

The investigators have found that sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, inhibits histone deacetylase (HDAC) activity in human colorectal and prostate cancer cells.

Conditions

  • Prostate Cancer Prevention

Interventions

DRUG

SFN-rich broccoli sprout extract capsules

Four weeks SFN-rich broccoli sprout extract (BSE) capsules: 200µmol of SFN, 2 capsules (1 capsule B.I.D.) daily

DIETARY_SUPPLEMENT

Gelatin capsule containing microcrystalline cellulose.

Four weeks placebo capsules: 2 capsules (1 capsule B.I.D.) daily

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • Oregon State University

    collaborator OTHER

  • OHSU Knight Cancer Institute

    collaborator OTHER

  • Portland VA Medical Center

    lead FED

Principal Investigators

  • Jackilen Shannon, PhD · Portland VA Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-07-31
Primary Completion
2015-10-31
Completion
2015-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01265953 on ClinicalTrials.gov