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Dietary Histone Deacetylase Inhibitors (HDAC)

NCT01543074 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 23

Last updated 2019-04-30

Study results available
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Summary

This pilot, three-week study will help scientists understand more about how the foods people eat can modify histone deacetylases, enzymes the body produces naturally. Broccoli sprout extract (BSE) and garlic oil are thought to modify these enzymes. The purpose of this study is to see if taking broccoli sprout extract alone, garlic oil alone, or broccoli sprout extract and garlic oil together, can decrease the action of histone deacetylase (HDAC) and turn on genes in white blood cells. There will be 80 people in this study.

Conditions

  • Histone Deacetylase (HDAC) Activity

Interventions

DIETARY_SUPPLEMENT

BSE placebo

2 pills = 0 micromoles of Sulforaphane/day

DIETARY_SUPPLEMENT

Garlic oil

1 pill = 30 mg garlic oil/day

DRUG

BSE

2 pills = 200 micromoles of Sulforaphane/day

DIETARY_SUPPLEMENT

Garlic Oil Placebo

1 pill = 0 mg garlic oil/day

Sponsors & Collaborators

Principal Investigators

  • Roderick Dashwood, PhD · Texas A&M University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-02-28
Primary Completion
2013-12-31
Completion
2013-12-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01543074 on ClinicalTrials.gov