The Bioavailability Of Sulforaphane From Broccoli Soups Study (BOBS)

Summary

There is current evidence that suggests eating cruciferous vegetables like broccoli, cauliflower, cabbage is beneficial to our health as they contain compounds which are thought to reduce the risk of diseases such as cancer and cardiovascular diseases. Cruciferous vegetables are able to deliver in our body a group of compounds called isothiocyanates (ITCs) that are thought to be responsible of their health-promoting effects. Sulforaphane (SF) from broccoli is one of the most studied ITCs and its anticancer properties have been extensively investigated in in vitro and in vivo models.

The investigators propose to undertake an intervention study to measure the bioavailability of SF from the soups used in another intervention study called ESCAPE. The investigators would like to investigate the rate and extent to which SF reaches the systemic circulation and is excreted in urine by measuring SF and its metabolites in plasma and urine samples collected from apparently healthy participants after consumption of the three types of broccoli + stilton soups. The three types of soups are standard broccoli + stilton soups and two high-glucoraphanin (SF precursor) broccoli + stilton soups which are able to deliver different levels of SF.

This study has been funded by Biotechnology and Biological Sciences Research Council (BBSRC) and Prostate Cancer foundation (PCF).

Conditions

• Healthy

Interventions

DIETARY_SUPPLEMENT

Standard broccoli and stilton soup

Participants will be randomised to eat one portion (300g) of broccoli soup for each phase.

DIETARY_SUPPLEMENT

Beneforte broccoli and stilton soup

Participants will be randomised to eat one portion (300g) of broccoli soup for each phase.

DIETARY_SUPPLEMENT

Beneforte Extra broccoli and stilton soup

Participants will be randomised to eat one portion (300g) of broccoli soup for each phase.

Sponsors & Collaborators

• Biotechnology and Biological Sciences Research Council

  collaborator OTHER

• Prostate Cancer Foundation

  collaborator OTHER

• Quadram Institute Bioscience

  lead OTHER

Principal Investigators

• Richard Mithen, PhD · Quadram Institute Bioscience

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2014-10-31

Primary Completion

2015-08-31

Completion

2015-08-31

Countries

• United Kingdom

Study Locations