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7T MRS in Parkinson's Disease

NCT01237210 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 78

Last updated 2019-11-01

No results posted yet for this study

Summary

This study is looking for healthy controls and patients with Parkinson's (PD) to perform an MR scan.

1. The neurochemical profile of the SN of patients with PD as measured by high field MRS will differ from that of healthy controls, in that glutathione will be lower due to oxidative stress, lactate will be higher due to mitochondrial dysfunction, the gliosis markers myo-inositol and glutamine will be higher due to inflammation (glial activation) and N-acetylaspartate and glutamate will be lower due to neuronal loss/damage.
2. There will be a relationship between neurochemical changes and disease severity.

Conditions

Sponsors & Collaborators

Principal Investigators

  • Paul Tuite, MD · University of Minnesota

Eligibility

Min Age
45 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-02-28
Primary Completion
2019-02-28
Completion
2019-02-28

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01237210 on ClinicalTrials.gov