Exercise Program Combined or Not With Nutritional intErvention in Adults With tyPe 2 Diabetes

Summary

Inactivity and excess energy consumption are leading causes of obesity and type 2 diabetes which are associated with increased cardio-metabolic risk. In order to reduce the cardiovascular risk associated with type 2 diabetes, the Canadian Diabetes Association guidelines (2008) recommends weight loss through caloric restriction and structured physical activity. However, the comparative effects of different methods to obtain caloric deficit for weight loss remains to be elucidated. The main objective of this study is to assess the impact of two strategies of caloric deficit: diet alone or diet and exercise on total fat mass, epicardial fat and cardiovascular risk factors in overweight and obese adults with type 2 diabetes and at high risk of cardiovascular disease.

Conditions

• Overweight
• Obesity
• Type 2 Diabetes

Interventions

BEHAVIORAL

Caloric restriction

The caloric restriction diet will follow the Canadian Diabetes Association guidelines and be nutritionally balanced with a reduced total fat as well as saturated content.

BEHAVIORAL

Diet intervention and structured exercise training program

Participants will follow the diet intervention previously described and a supervised physical activity program. The supervised exercise training sessions will take place three times a week for 4 months. Each session will last 1hour and will include aerobic exercise and resistance training. The aerobic training program will be treadmills intervals exercise at 50-70 % of heart rate reserve(HRR) the first month and 85-90% of HRR from the second to the fourth month. The resistance training programme will consist of two to three sets of 12 repetitions of the following exercises: leg press, chest press, lat pulldown, shoulder press, biceps curl, triceps extension.

Sponsors & Collaborators

• Institut de Recherches Cliniques de Montreal

  lead OTHER

Principal Investigators

• Remi Rabasa-Lhoret, MD, PhD · Institut de Recherches Cliniques de Montreal

• Antony Karelis, PhD · Université de Québec à Montréal

• Denis Prud'Homme, MD, Msc · University of Ottawa

• Eric Doucet, PhD · University of Ottawa

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

30 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-09-30

Primary Completion

2016-04-30

Completion

2016-04-30

Countries

• Canada

Study Locations