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Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic Shock

NCT04494074 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 820

Last updated 2024-12-10

No results posted yet for this study

Summary

The best strategy for managing fever in patients with septic shock remains unknown. In a pilot study, the investigators showed that fever control at normothermia allowed a better control of shock and evolution of organ failures. In this second trial the investigators will conduct a multicentre, open-label, randomized controlled, superiority trial in which two strategies will be compared:

1. Respect of fever
2. Fever control at normothermia using external cooling The primary end point will be d-60 mortality.

Conditions

  • Septic Shock

Interventions

OTHER

External Cooling

External Cooling

Sponsors & Collaborators

  • Centre Hospitalier Intercommunal Creteil

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-10-01
Primary Completion
2026-12-01
Completion
2026-12-01

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04494074 on ClinicalTrials.gov