MedTrace Logo

Respiratory Muscle Dysfunction in Critically Ill Patients

NCT01104857 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2015-06-10

No results posted yet for this study

Summary

Respiratory muscle dysfunction in critically ill patients is associated with elevated morbidity, including prolonged weaning from mechanical ventilation. The causes for respiratory muscle dysfunction in these patients is poorly understood and no effective treatment is available.

The general hypothesis of the present study is that in critically ill mechanically ventilated subjects respiratory muscle dysfunctions results from loss of myosin induced by activation of proteolytic cascades.

Conditions

  • Sepsis
  • Mechanical Ventilation

Interventions

PROCEDURE

diaphragm muscle biopsy

Biopsy is obtained for biochemical analysis

PROCEDURE

Diaphragm muscle biopsy

Biopsy is obtained for biochemical analysis

Sponsors & Collaborators

  • University Medical Center Nijmegen

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-04-30
Primary Completion
2016-04-30
Completion
2016-04-30

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01104857 on ClinicalTrials.gov