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Diaphragmatic Atrophy Related to Mechanical Ventilation

NCT02766946 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 97

Last updated 2024-04-04

No results posted yet for this study

Summary

Ventilatory support during critical phase result in inactivity of respiratory muscles especially diaphragm muscle. These inactivity also result in change of contractile capability and quick muscular atrophy.

The aim of the study is to visualize the evolution of diaphragm thickness by echography during Mechanical Ventilation for patients with septic shock or acute respiratory distress syndrome and to compare with the evolution for patients under non-invasive ventilation and those with spontaneous ventilation. Measurements will be performed at day 1, day 5 and day 10 (if patient still under a mode of ventilation or in the unit).

The evolution of diaphragm thickness will also be compared to pectoralis muscle atrophy, which is not involved in ventilation, in order to assess respective effect of ventilatory inactivity and undernutrition linked to intensive care.

Conditions

  • Septic Shock
  • Acute Respiratory Distress

Interventions

DEVICE

Ultrasound

An ultrasound of the right diaphragm will be performed on day 1, day 3, day 5 and day 10

DEVICE

Ultrasound

An ultrasound of the pectoral muscle will be performed on day 1, day 3, day 5 and day 10

OTHER

Neuromyopathy score

A neuromyopathy score will be assessed on the extubation day

OTHER

Respiratory performances

An assessment of the respiratory performances will be done on the extubation day, including higher expiratory pressure, higher inspiratory pressure, and occlusion pressure

Sponsors & Collaborators

  • Centre Hospitalier Saint Joseph Saint Luc de Lyon

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-06-24
Primary Completion
2015-12-17
Completion
2015-12-22

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02766946 on ClinicalTrials.gov