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Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes

NCT05857774 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 230

Last updated 2024-05-21

No results posted yet for this study

Summary

Air is normally pumped in and out of the lungs by the muscles that contribute to inhalation and exhalation, called the respiratory muscles. The abdominal muscles help by forcing air out of your lungs during exhalation; whereas the diaphragm, the main muscle used for breathing, contracts to get air into the lungs during inhalation. With mechanical ventilation, respiratory muscles are able to rest and recover while the breathing machine takes over; however, this may cause respiratory muscle weakness. Patients who develop weakness of these muscles may require more assistance from the ventilator and take longer to recover their ability to breathe without assistance. The impact of this phenomenon on long-term outcomes is uncertain.

The RESPIRE study is designed to characterize how respiratory muscles change during mechanical ventilation and to evaluate the impact on long term quality of life. An additional objective of this study is to examine novel measures obtained from automated functions of a ventilator, that may better predict success from weaning from mechanical ventilation.

Conditions

  • Mechanical Ventilation Complication
  • Diaphragm Injury
  • Lung Injury
  • Respiratory Insufficiency
  • Abdominal Muscle Strained

Interventions

OTHER

Sonographic measurements

Diaphragm thickness, diaphragm tidal thickening fraction, abdominal muscle thickness, rectus femoris cross-sectional area, maximal diaphragm thickening fraction, abdominal muscle thickening fraction

OTHER

Physiological measurements

Airway occlusion pressure, maximal inspiratory pressure, muscle research council score

OTHER

Biological measurements

Skeletal troponin-I

Sponsors & Collaborators

  • University Health Network, Toronto

    lead OTHER

Principal Investigators

  • Ewan Goligher, MD, PhD · University Health Network, Toronto

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-27
Primary Completion
2025-12-31
Completion
2026-06-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05857774 on ClinicalTrials.gov