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Internal Monitoring of Eye Movement in Schizophrenia

NCT01011101 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 2

Last updated 2017-10-06

No results posted yet for this study

Summary

Background:

* Researchers are studying how humans are able to move our eyes to a remembered region even when the target has disappeared. The ability to do this suggests that the brain can keep track of where the eyes have looked, without an external target for continued reference. This is called corollary discharge.
* Other research has indicated that patients with schizophrenia might have difficulty monitoring their eye movements. The corollary discharge process may be defective in patients with schizophrenia, and perhaps delayed in time. Researchers have developed a test to examine this possibility in the hope of learning more about schizophrenia and eye movement.

Objectives:

\- To assess whether there is a defect in internal monitoring of eye movements in patients with schizophrenia.

Eligibility:

* Individuals over 18 years of age who are able to give informed consent and are able to concentrate on a 20-minute task that involves following projected targets and moving their eyes to remembered locations.
* Individuals with schizophrenia will be recruited from an ongoing NIH protocol studying schizophrenia.
* In addition healthy will be recruited for this protocol.

Design:

* Researchers will check participants' vision in each eye, and ask them to sit at a machine that measures eye movement in order to complete research tasks. Researchers will monitor participants ability to complete these tasks.
* The first task involves simply following a target that jumps to different parts of the screen.
* The second is a 2-step task, in which a participant is asked to look at two separate light targets and then look at the remembered target positions when the lights are off.
* This protocol does not provide treatment. Participants will remain under the care of their own physicians during participation in this protocol.

Conditions

Sponsors & Collaborators

  • National Eye Institute (NEI)

    lead NIH

Principal Investigators

  • Edmond J FitzGibbon, M.D. · National Eye Institute (NEI)

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-11-02
Completion
2016-08-16

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01011101 on ClinicalTrials.gov