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Deep Brain Stimulation (DBS) Frequency Effects on Gait in Parkinson's Disease(PD)

NCT00993291 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2012-01-27

Study results available
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Summary

In this study the investigators will evaluate the effect of both low and high frequency Deep Brain stimulation of the subthalamic nucleus (STN) in Parkinson's patients who have noted a change in their walking. The investigators' hypothesis is:

1. Stimulation at 60 Hertz (Hz) is associated with improved gait with increased stride length and faster time on the Stand walk sit test.
2. There is no worsening of the Unified Parkinson's Disease Rating Scale (UPDRS) at 60 Hz.

Conditions

  • Parkinson Disease

Interventions

PROCEDURE

Frequency change to 60 Hz

60 Hz stimulation for one hour, done twice over the 5 hour study period in a randomized blinded fashion.

PROCEDURE

Frequency change to 130 Hz

130 Hz Stimulation for one hour, done twice over the 5 hour study period in a randomized blinded fashion.

Sponsors & Collaborators

  • Vanderbilt University

    lead OTHER

Principal Investigators

  • Fenna T Phibbs, MD · Vanderbilt Univeristy

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
DOUBLE
Model
SINGLE_GROUP

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-11-30
Primary Completion
2011-08-31
Completion
2011-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00993291 on ClinicalTrials.gov