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Combined Deep Brain Stimulation in Parkinson's Disease

NCT05415774 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2026-05-06

No results posted yet for this study

Summary

The study is a pilot study on Parkinson's disease patients to evaluate Combined deep brain stimulation of the substantia nigra pars reticulata and of the subthalamic nucleus for unresponsive freezing of gait.

Conditions

  • Parkinson Disease

Interventions

DEVICE

6 : C2 - C1 - S

Deep brain stimulation of the substantia nigra pars reticulata and of the subthalamic nucleus according to the order of randomisation (see intervention name) : * Standard stimulation * 125Hz at both STN and SNr for C1, * 125Hz for STN and 60 for SNr for C2

DEVICE

1 : S-C1-C2

Deep brain stimulation of the substantia nigra pars reticulata and of the subthalamic nucleus according to the order of randomisation (see intervention name) : * Standard stimulation * 125Hz at both STN and SNr for C1, * 125Hz for STN and 60 for SNr for C2

DEVICE

2 : S-C2-C1

Deep brain stimulation of the substantia nigra pars reticulata and of the subthalamic nucleus according to the order of randomisation (see intervention name) : * Standard stimulation * 125Hz at both STN and SNr for C1, * 125Hz for STN and 60 for SNr for C2

DEVICE

3 : C1 - S - C2

Deep brain stimulation of the substantia nigra pars reticulata and of the subthalamic nucleus according to the order of randomisation (see intervention name) : * Standard stimulation * 125Hz at both STN and SNr for C1, * 125Hz for STN and 60 for SNr for C2

DEVICE

4 : C1 -C2 - S

Deep brain stimulation of the substantia nigra pars reticulata and of the subthalamic nucleus according to the order of randomisation (see intervention name) : * Standard stimulation * 125Hz at both STN and SNr for C1, * 125Hz for STN and 60 for SNr for C2

DEVICE

5 : C2 - S - C1

Deep brain stimulation of the substantia nigra pars reticulata and of the subthalamic nucleus according to the order of randomisation (see intervention name) : * Standard stimulation * 125Hz at both STN and SNr for C1, * 125Hz for STN and 60 for SNr for C2

Sponsors & Collaborators

  • University Hospital, Toulouse

    lead OTHER

Principal Investigators

  • Margherita FABBRI, MD · University Hospital, Toulouse

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-09
Primary Completion
2023-05-10
Completion
2023-05-10

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05415774 on ClinicalTrials.gov