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Comparative Study of Rocuronium With Vecuronium (Study 71101)(COMPLETED)

NCT00970762 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2015-04-17

No results posted yet for this study

Summary

This study was conducted to determine and compare the safety and effectiveness of two neuromuscular blockers (rocuronium and vecuronium) at various doses in adults who are undergoing general elective surgery with sevoflurane anesthesia.

Study participants received an intubating dose of a neuromuscular blocker (to enable insertion of a tube through the nose or mouth into the trachea to provide artificial ventilation). The intubating dose was followed by repeated bolus maintenance doses as needed, to maintain muscle relaxation. The time it takes to reach maximal effect of the neuromuscular blocker (onset time) after the intubating dose was measured and compared as the primary outcome.

Conditions

  • Anesthesia

Interventions

DRUG

Rocuronium 0.6 mg/kg intubating dose

Rocuronium 0.6 mg/kg intubating dose

DRUG

Rocuronium 0.9 mg/kg intubating dose

0.9 mg/kg intubating dose of rocuronium

DRUG

Rocuronium 0.1 mg/kg maintenance dose

Rocuronium 0.1 mg/kg maintenance dose following the intubating dose.

DRUG

Rocuronium 0.15 mg/kg maintenance dose

Rocuronium 0.15 mg/kg maintenance dose following the intubating dose

DRUG

Rocuronium 0.2 mg/kg maintenance

Rocuronium 0.2 mg/kg maintenance dose following the intubating dose

DRUG

Vecuronium 0.1 mg/kg intubating dose

Vecuronium 0.1 mg/kg intubating dose

DRUG

Vecuronium 0.025 mg/kg maintenance dose

Vecuronium 0.025 mg/kg maintenance dose following the intubating dose

Sponsors & Collaborators

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2003-02-28
Primary Completion
2004-02-29
Completion
2004-02-29

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00970762 on ClinicalTrials.gov