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Influence of the Neuromuscular Blockade on Mask Ventilation

NCT02318810 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 300

Last updated 2016-05-03

No results posted yet for this study

Summary

Mask ventilation during induction of anesthesia can be improved by administration of neuromuscular blocking agents (NMBAs). NMBAs are usually administered after testing mask ventilation; however, muscle relaxants may improve mask ventilation and they do not alter mask ventilation. Thus, growing evidence suggests to administer muscle relaxants before testing mask ventilation. We will study different dosages of rocuronium; we assume that higher dosages of rocuronium will improve mask ventilation compared with lower dosages.

Conditions

  • Complication of Ventilation Therapy
  • Observation of Neuromuscular Block

Interventions

DRUG

Rocuronium 0.3 mg/kg

Patients receive rocuronium 0.3 mg/kg

DRUG

Rocuronium 0.6 mg/kg

Patients receive rocuronium 0.6 mg/kg

DRUG

Rocuronium 0.9 mg/kg

Patients receive rocuronium 0.9 mg/kg

DRUG

Placebo

Patients receive saline

Sponsors & Collaborators

  • University of Rostock

    lead OTHER

Principal Investigators

  • Thomas Mencke, Prof. · University of Rostock

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-03-31
Primary Completion
2016-05-31
Completion
2016-05-31

Countries

  • Germany

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02318810 on ClinicalTrials.gov