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Effect of Rocuronium and Sugammadex Under Sevoflurane and Desflurane Anesthesia in Children

NCT03795259 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 148

Last updated 2021-05-04

No results posted yet for this study

Summary

Sugammadex is the first selective relaxant binding agent approved to reverse certain non-depolarizing neuromuscular drugs in patients 2 years old and above. Although it has been in use over the last 10 years, more pharmacological studies are needed to understand its overall effects on participants.

As investigators' primary outcome, the investigators aimed to investigate how differently sugammadex reverses neumuscular blockade caused by rocuronium under general anesthesia maintenance with sevoflurane compared with desflurane. Also, to compare the changes in peak airway pressure. As investigators' secondary outcome, the investigators aimed to compare the changes in heart rate and blood pressures after sugammadex injection under sevoflurane and desflurane general anesthesia.

Conditions

  • Anesthetics, Inhalation
  • Neuromuscular Blockade
  • Anesthesia, General

Interventions

DRUG

Rocuronium

After induction, rocuronium 0.6 mg/kg will be given by intravenously and patients will be orotracheal intubated when TOF value reaches 0%.

DRUG

Sugammadex

Continuous TOF measurement will continue until the value reaches %25. At this time, sugammadex 2 mg/kg will be given intravenously.

Sponsors & Collaborators

  • GAMZE PİRİNÇ ŞAŞIOĞLU

    collaborator UNKNOWN

  • GÜNER KAYA

    collaborator UNKNOWN

  • Ayse Cigdem Tutuncu

    collaborator OTHER

  • Istanbul University

    lead OTHER

Principal Investigators

  • Guner Kaya, Prof. · Istanbul University Cerrahpasa Medical Faculty

Study Design

Allocation
RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
2 Years
Max Age
10 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-12-28
Primary Completion
2019-05-19
Completion
2019-05-19

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03795259 on ClinicalTrials.gov