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Autonomic Nervous System Function Following Bariatric Surgery

NCT00948545 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 37

Last updated 2012-11-07

No results posted yet for this study

Summary

In the proposed study, the investigators will explore three specific aims. First, the investigators will examine cross-sectionally the association of obesity on sympathetic, parasympathetic, and sympathetic/ parasympathetic nerve fiber balance. In addition, the investigators will determine the relationship of the ANS and osteocalcin. Osteocalcin will be measured before and after a mixed meal tolerance test.

In the second specific aim, the investigators will prospectively follow-up these individuals (n=30) following bariatric surgery. The effect of weight loss on measures of the ANS and osteocalcin will be examined 6 months following surgery with participants serving as their own control, pre- and post-surgical intervention.

Thirdly, the investigators will address whether the effect of weight loss on the ANS and osteocalcin differ between those who had a history of diabetes at baseline versus those with no history of diabetes.

Conditions

  • Bariatric Surgery

Interventions

OTHER

Observational study - there is no intervention

Observational study - there is no intervention

Sponsors & Collaborators

  • American Society for Metabolic and Bariatric Surgery

    collaborator OTHER

  • Christiana Care Health Services

    lead OTHER

Principal Investigators

  • M James Lenhard, MD · Christiana Care Health Services

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-07-31
Primary Completion
2011-06-30
Completion
2012-04-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00948545 on ClinicalTrials.gov