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Autonomic Neural Blockade in Bariatric Surgery

NCT07104825 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2026-01-29

No results posted yet for this study

Summary

The purpose of this research is to evaluate if autonomic nerve block (ANB- blocking pain and nausea signals) decreases pain and anti-nausea medication requirements as well as the experience of pain/nausea during the first 72 hours after sleeve gastrectomy or gastric bypass surgery. Participants will be randomly assigned either to the standard of care or the ANB group before surgery. As part of standard of care, in both groups, laparoscopic bariatric surgery will be initiated with local anesthetic injected into the abdominal wall. In the ANB group, participants will be given an additional injection of local anesthetic medication to block nerves on and around the stomach.

Conditions

  • Bariatric Surgery Candidate
  • Pain, Postoperative
  • Nausea and Vomiting, Postoperative
  • Opioid Use

Interventions

PROCEDURE

Intraoperative autonomic neural blockade (ANB)

Local anesthetic block of the neurovascular tissue along the lesser curve of the stomach and celiac trunk during sleeve gastrectomy or gastric bypass surgery.

PROCEDURE

Laparoscopic Standard of Care Abdominal Wall Block

Administration of local anesthetic to abdominal incisions (standard of care)

Sponsors & Collaborators

  • Endeavor Health

    lead OTHER

Principal Investigators

  • Herbert Hedberg, MD · Endeavor Health

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-31
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07104825 on ClinicalTrials.gov